内镜活检食管癌组织中CD_(44V6)蛋白的检测及意义

Esophagoscopy:Detection on Adhesion Molecule CD_(44V6) in Esophageal Squamous Cell Carcinoma and Its Significance

目的 探讨内镜活检组织CD44V6的表达与食管癌临床病理及预后的关系。方法 对 6 4例食管癌活检标本 ,应用SP免疫组织化学染色法进行CD44V6检测 ,并对其中 4 5例进行了术后 3年随访。结果 CD44V6蛋白表达与患者年龄、性别及肿瘤分化程度无关 (P >0 .0 5 ) ;与食管癌的浸润、转移、复发与预后均有关 (P <0 .0 5 )。结论 CD44V6与食管癌侵袭、转移和预后有关 。

Objective To study the expression of CD 44V6 and its clinical significance in patients with esophageal squamous cell carcioma undergoing esophagoscopy.Methods CD 44V6 expression was determined in esophagoscopy tissues from 64 esophageal squamous cell carcinoma with immunohistochemical methods.45 cases were followed up for 3 years .Results Expression of CD 44V6 was not related with age ,sex ,cellular differentiation in patients with esophageal squamous cell carcioma (P>0.05).The correlation was observed between CD 44V6 expression and the invasion,metastasis and prognosis in esophageal squamous cell carcinoma (P<0.05).Conclusion CD 44V6 expression was related with invasion,metastasis,and prognosis in patient with esophageal sguamous cell carcinoma,and it can be regarded as an important sign of the carcinoma invasion and metastasis.