杜仲对兔骨折端骨密度影响的实验研究

Effect of Cortex Eucommiae on Dinsity of Fracture

目的 :研究单味中药杜仲在治疗创伤性骨折方面有无促进骨折愈合的作用。方法 :手术造出日本大耳白兔胫骨中下段 1 / 3交界处骨折及骨缺损模型 45只 ,随机分成治疗组和对照组 ,分别给予杜仲水煎液及生理盐水灌胃 ,并在造模后分别进行骨密度测定 ,对其数据进行统计学分析。结果 :治疗组 (n =2 3只 )与对照组(n =2 2只 )相比较 ,从第 7天开始直至骨折愈合 ,治疗组骨密度高于对照组 (P <0 0 5或P <0 0 1 ) ,且发现治疗组从第 7天开始 ,骨折线远侧的骨密度明显大于骨折线近侧 (P <0 0 5或P <0 0 1 ) ,直到第 37天远近端的差异才消失 ;对照组从第 1 7天开始 ,骨折线远侧的骨密度明显大于骨折线近侧 (P <0 0 5或P <0 0 1 ) ,直到第 47天远近端的差异才消失 ,但比治疗组晚了 1 0天左右。结论 :杜仲水煎液内服能促进骨折断端矿物质的沉积。

AIM: study the effect of Cortex Eucommiae on treating fractures induced by extemal forces and on improving union. METHODS: According to the literatures, animal fracture models were made in the left tibias of 45 rabbits. All these were devided into the Experiment Groups which were fed by Cortex Eucommiae and the control One which were fed by physiological saline. They would be measured by DEXA at intervals of different time. The datas from the experiment were analysed. Results: The density of fracture site from the experiment group was higher than that from the other one on the 7th day (P<0.05 or P<0.01). Also it was found that the density of the far site was higher than the nearer site (P<0.05 or P<0.01). But in the control one the density of the far site was higher than the nearer from the 17 th day (P<0.05 or P<0.01). CONCLUSION: Cortex Eucommiae which is taken orally can accelerate the union of rabbits.