网上生物信息学数据库资源

Bioinformatics Database Resources on Internet

大量的蛋白质和核酸数据的积累与理性地分析这些数据中所蕴涵的生物学意义的双重需要 ,产生了综合生物学研究与计算技术研究等领域最新成果的交叉性学科生物信息学。本文分别从生物信息学的基因组数据库 ,核酸和蛋白质一级结构序列数据库 ,生物大分子 (主要是蛋白质 )三维空间结构数据库 ,以及以这 3类数据库和文献资料为基础构建的二次数据库 (包括基因组二次数据库、蛋白质序列二次数据库、蛋白质结构二次数据库 )和生物信息学数据库的集成系统等几个方面 ,概述了发展中的生物信息学数据库的最近动态和有关信息 ,同时对主要的热门生物信息学数据库站点和资源进行了评价。此外 ,就国内生物信息学数据库存在的问题与前景进行了讨论 ,指出生物信息学将是一次国际性的科学大协作 ,也是我国生命科学振兴的一个新契机。

Bioinformatics came from the requirement for vast data of protein and nucleic acids and analysis of the biological significance implying in these data. It is an intercross subject which integrates the newest reaching outcomes of biology, computer technology and other fields. The paper summarizes the newest developments and relative information of bioinformatics database from some respects such as genome database, first class database of protein and nucleic acids sequence, three dimensional spatial structure database of biomacromolecules (protein is dominating), sub databases including genome database, protein sequence sub database and protein structure sub database, which are all constructed on the first class databases, references, and the integrated system of bioinformatics database . At the same time, evaluation about the main hot nets of bioinformatics database and resources is given out. Furthermore, the problems and prospects of domestic bioinformatics database are discussed. Bioinformatics will be an international collaborative venture of modern science. Bioinformatics also will be a chance to develop our life science.