老年高血压病患者血浆中NO、ET的变化及雷米普利对其影响

Changes of ET and NO in blood plasma in aged patients with essential hypertension and the effect of ramipril

目的 探讨老年高血压病患者血浆中 NO、ET的变化及雷米普利对其影响。方法 观察雷米普利 (2 .5～ 1 0 mg,每日一次口服 ,8w)治疗的单纯高血压 (EH) 36例患者治疗前后血浆 ET、NO水平 ,并与 30例健康者作对照。结果 EH患者 ET较对照组显著升高 (P<0 .0 1 ) ,NO显著降低 (P<0 .0 1 ) ,经雷米普利治疗后 ,收缩压及舒张压都有显著性下降 (P<0 .0 1 ) ,ET显著下降 (P<0 .0 1 ) ,NO显著升高 (P<0 .0 1 )。结论 高血压病的发生与上述血管活性物质水平的变化有关 ,雷米普利在降压同时能改善血管内皮功能。

Objective To discuss the changes of ET and NO in plasma in aged patients with essential hypertension and the effect of Ramipril.Methods To detect NO and ET level of 30 cases of normal persons and 36 cases of elderly hypertension patients; 36 patients were treated with Ramipril 2.5 mg～10 mg qd po for eight weeks, monitoring the blood pressure before and after treatment, examining the endothelin (ET) and nitric oxide (NO) by radioimmunoassay.Results ①ET level is higher than contrast group and NO level is lower than contrast group in aged hypertension patients (P<0.01). ②After treatment of Ramipril, ET level decreases and NO level increases (P<0.01).Conclusions Hypertension relates with the changes of the levels of vascular active substance, Ramipril can decrease the blood pressure and simultaneously also can improve the vascular endothelial function.