促红细胞生成素对老年血液透析患者血管活性介质的影响

Effect of recombinant human erythropoietin on vasoactive substances in aged maintenance haemodialysis patients

目的 探讨基因重组促红细胞生成素 (r Hu EPO)对老年维持性血液透析患者血管活性介质的影响。方法 39例基础血压正常的血透患者 ,其中 2 1例静脉 1次注射 r Hu EPO 30 0 0 U(EPO组 ) ,1 8例作为对照 (NS组 )静脉注射生理盐水。均于注射后 1、3、6、9、1 2、1 8、2 4、30、44 h放射免疫法等检测血中血管活性介质。 1 2例 EPO组患者应用 r Hu EPO60 0 0 U/ w,持续 8w后再检血中血管活性介质。结果 与 NS组相比 ,EPO组儿茶酚胺 (CA)明显升高 ;血中内皮素、肾素、醛固酮和血管紧张素 I、II两组均无明显变化。结论 r Hu EPO可引起老年血透患者血中 CA增多。

Objective To explore the effect of recombinant human erythropoietin (rHuEPO) on vasoactive substance in aged maintenance haemodialysis patients. Methods In 39 adenced normotensive patients on maintenance haemodialysis , 21 cases as EPO group were given a bolus venous injection of rHuEPO 3000 IU, the others (n=18) were injected 0.9% sodium as control group(NS group). The plasma vasoactive substance was assayed at basis and 1?3?6?9?12?18?24?30?44 hours after therapy with or without rHuEPO by radioimmunol method etc. Twelve cases of EPO group were received 6000IU/week rHuEPO therapy, and vasoactive substance was assayed after 8 weeks.Results (1) The plasma catecholamine(CA) increased observably in EPO group compared to NS group. (2) Endothelin , rennin activity, aldosterone and angiotensin I, angiotensin Ⅱ levels were no changes in EPO group and NS group .Conclusions The rHuEPO could increase the plasma CA in aged maintenance haemodialysis patients.