益肾解毒方延缓慢性肾功能衰竭的临床观察

Clinical Observation on Effect of Yishen Jiedu Recipe in Retarding the Course of Chronic Renal Failure

目的 :观察中药益肾解毒方对延缓慢性肾功能衰竭 (CRF)进展的作用。方法 :4 5例CRF患者分为两组 ,对照组 (A组 ) 2 2例单纯予低蛋白饮食及控制高血压治疗 ;治疗组 (B组 ) 2 3例在A组治疗基础上加用益肾解毒方治疗。以计算两组SCr值升高 1倍时所经历的时间 (月 )之方法评估CRF的进展速度。结果 :A组SCr由 (2 88 4± 96 7) μmol/L升高至 (5 86 3± 2 5 1 3) μmol/L历时 (16 7± 5 1)个月 ;B组SCr由(2 91 2± 10 1 2 ) μmol/L升高至 (5 89 6± 2 5 7 5 ) μmol/L历时 (2 8 2± 8 7)个月 ,两组比较差异有显著性 (P<0 0 5 )。结论 :在低蛋白饮食和控制高血压的基础上加用中药益肾解毒方 ,可使CRF进展速度明显延缓。

Objective: To observe the effect of Yishen Jiedu Recipe (YSJDR) in retarding the course of chronic renal failure (CRF). Methods: Forty five patients were divided into two groups, the 22 patients in Group A were treated with low protein diet and blood pressure controlling therapy only, while the 23 patients in Group B were treated with additional YSJDR. The time (month) for doubling serum creatinine (SCr) level was taken to evaluate the speed of CRF progression. Results: In Group A, the time for SCr increased from 288 4±96 7 μmol/L to 586 3±251 3 μmol/L was 16 7±5 1 months, while in Group B the time for SCr increased from 291 2±101 2 μmol/L to 589 6±257 5 μmol/L was 28 2±8 7 months. Comparison between the two groups showed significant difference (P<0 05). Conclusion: On the basis of low protein diet and blood pressure controlling therapy, the additional treatment of YSJDR could markedly retard the progression speed of CRF.