健脾温肾汤对糖尿病腹泻患者血清胃泌素、血浆胃动素及生长抑素的影响

Effect of Jianpi Wenshen Decoction on Serum Gastrin, Plasma Motilin and Somatostatin in Patients of Diabetic Diarrhea

目的 :观察健脾温肾汤对糖尿病腹泻患者血清胃泌素、血浆胃动素及生长抑素的影响。方法 :将糖尿病腹泻患者随机分为两组 ,一组采用自拟健脾温肾汤 (简称中药组 )治疗 ,另一组采用易蒙停 (简称西药组 )治疗 ,并设立正常对照组 ,观察血清胃泌素、血浆胃动素及生长抑素水平的变化。结果 :治疗前 ,两组患者血清胃泌素、血浆胃动素水平明显高于正常对照组 ,血浆生长抑素水平低于正常对照组。治疗 1个月后 ,两组患者血清胃泌素、血浆胃动素水平均明显下降 ,血浆生长抑素水平明显增高 ,虽仍低于正常对照组 ,但与正常对照组比较差异无显著性 (P >0 0 5 )。血清胃泌素、血浆胃动素水平在临床治愈、显效、有效、无效的测定值呈逐渐升高趋势 ,生长抑素水平则呈现下降趋势。结论 :通过对糖尿病腹泻患者血清胃泌素、血浆胃动素、生长抑素水平的观察 ,证明了健脾温肾汤能促进受损植物神经功能的恢复 ,同时上述激素水平的变化可作为评价糖尿病腹泻疗效的一项指标。

Objective: To observe the effect of Jianpi Wenshen Decoction (JWD) on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea (DD). Methods: Patients with DD were randomly divided into two groups, the JWD group and the control group treated with Loperamide (LPA). Besides, a normal control group was set up. Changes of serum gastrin, plasma motilin and somatostatin were observed. Results: Before treatment, the levels of gastrin and motilin in both groups were higher and somatostatin lower than those in the normal control group. After 1 month treatment, levels of the three indices were restored in both group approaching the normal range with insignificance as compared with those in the normal control group (P>0 05). Level of plasma motilin and serum gastrin showed an increasing trend along with the therapeutic effect elevation, while level of somatostatin showed a decreasing trend. Conclusion: JWD could promote the recovery of the impaired function of vegetative nerve system in DD patients. At the same time, serum gastrin, plasma motilin and somatostatin may be taken as the indexes for evaluating the efficacy in treating DD.