中药合剂对特重度烧伤患者免疫功能的影响

Effect of Clinese Drugs Mixture on Immune Function of Patients with Extremely Severe Burn

目的 :探讨中药合剂清火败毒饮对特重度烧伤患者免疫功能的调理作用。方法 :将 30例特重度烧伤患者分成两组 ,两组均进行常规治疗 ,中药组加用中药合剂治疗 ,治疗前及治疗后各时间段测定外周血中T淋巴细胞亚群和体液免疫功能 ,并判定两组治疗效果。结果 :与对照组比较 ,中药组CD3、CD4 、CD4 /CD8值下降程度轻 (P <0 0 5或P <0 0 1) ,CD8升高程度轻 (P <0 0 1) ,但均恢复快 ;IgG、IgA、IgM、C3、C4 值均有不同程度降低 (P <0 0 5或P <0 0 1) ,但中药组回升早 ,恢复快而好。结论 :中药合剂对特重度烧伤患者的细胞、体液免疫功能均有调理作用。

Objective: To study the regulatory effect of Qinghuo Baidu Yin (QHBDY, a mixture prepared with Chinese drugs) on immune function of patients with extremely severe burn (ESB). Methods: Thirty patients with ESB were divided into two groups, conventional therapy was given to both groups, but QHBDY was given to the treated group additionally. Immunological indices, including peripheral blood T lymphocyte subsets, immunoglobin (IgG, IgA and IgM) and complement (C 3 and C 4) were determined 3 weeks after treatment to evaluate and compare the therapeutical effect in the two groups. Results: Compared with the control group, CD 3, CD 4, CD 4/CD 8, immuoglobin (IgG, IgA and IgM) and complement (C 3 and C 4) levels were markedly decreased in degree, and recovered earlier and quicker, with CD 8 increased mildly (P<0 01) and turned back more quickly. And so did the parameters of the treated group in comparing with that of the control group at anytime (P<0 05 or P<0 01). Conclusion: Chinese drugs mixture shows the regulatory effect on both cellular and humoral immune function in patients with ESB.