亚硒酸钠联合抗痨药治疗HBV感染的肺结核病人临床研究

Clinical study on treatment of tuberculosis complicated with HBsAg with anti-tuberculosis drugs plus sodium selenite

目的 探讨亚硒酸钠联合抗痨药治疗HBV感染的肺结核病人的疗效及对肝功能的影响。方法 将病人随机分为联合抗痨组和单纯抗痨组 ,定期观察临床症状、体征、胸部影像学改变及痰菌含量变化 ,并检测肝功能指标。结果 联合抗痨组总有效率为 91 7% ,单纯抗痨组为 79 0 % (P <0 0 5) ;联合组肝损害率为 1 1 7% ,单纯组为 2 5 8% (P <0 0 5)。结论 亚硒酸钠联合抗痨药治疗肺结核优于单纯抗痨药物治疗 。

Objective To explore the therapeutical effect of treatment of tuberculosis complicated with HBsAg with anti tuberculosis drugs plus sodium selenite and their influence to hepatic function.Methods All patients were divided randomly into the group of combined treatment and another group of simple treatment.The patients' clinical symptoms and signs,X ray photograph and the change of the content of M·tuberculosis from phlegm were observed regularly and the liver function was tested regularly.Results The total efficieney rate of combined treatment was 91.7%,the efficiency rate of simple trenmert was 79%(P<0.05).The raties of liver injury in combined treatment group were 11.7%,and 25.8% in simple treatment group respectively(P<0.05).Conclusion The curative effect of tuberculosis with antituberculosis plus sodium selenite is better than that with simple antituber culous drugs.Sodium selenite have definitive protection against lesion of liver.