Endomorphin-1对佐剂性关节炎作用的研究

Effect of endomorphin-1 on adjuvant arthritis

目的 观察内吗啡肽 1 (endomorphin 1 ,EM 1 )对佐剂性关节炎动物的镇痛作用。 方法 制备大鼠佐剂性关节炎动物模型 ,采用钾离子透入法和辐射热 缩腿法两种测痛方法 ,观察腹腔注射EM 1 (50 μg/kg)的作用。 结果 EM 1对佐剂性关节炎急性期和慢性期的痛阈均有提高作用 ,并且EM 1的作用可被纳洛酮翻转。结论 EM

Objective To study the analgesic effect of endomorphine 1(EM 1) on adjuvant arthritis model.Methods The experiment was performed in rats which adjuvant arthritis was treated by K + iontophoresis test and radiant heat withdrawal test to study the analgesic effect of intraperitoneal(i.p.) of EM 1(50 μg/kg).Results EM 1 could raise the pain threshold in acute and chronic period of adjuvant arthritis model.The analgesic effect of EM 1 could be reversed by naloxone.Conclusion EM 1 has analgesic effect on adjuvant arthritis model.