静脉注射丙种球蛋白的溶液性质及稳定性研究

Studies on the Solution Properties and Stability of Immunoglobulin G for Intravenous

采用小角激光光散射法(LALLS)结合粘度测定,分别对在不同pH和离子强度下的人血免疫丙种球蛋白(IgG)溶液性质进行了研究。结果表明,IgG在溶液中存在着不同的结构层次,包括单体、二聚体、聚集体、聚集堆积至沉淀析出。水溶性高分子聚乙烯基吡咯烷酮(PVP)的加入有利于保护丙球单体的稳定,起着防止其自身聚集的作用。

The properties of Immunoglobulin G (IgG) solutions with different pH values and ion strengthes were investigated by means of low angle laser light scattering and viscosimetry. It was found that there were different Types of structure, including monomer molecules, dimers, aggregates and precipitates in the IgG solutions. The addition of water-soluble poly(vinyl- pyrrolidone) was effective for the stability of IgG monomer and prevented it from aggregation in the solution.