呋喃硝胺与胶体铋剂治疗胃溃疡的对比研究

COMPARISON OF RANITIDINE AND COLLOIDAL BISMUTHATE IN THE TREATMENT OF GASTRIC ULCER; A SINGLE-BLIND RANDOM TRIAL

对胃镜诊断的良性胃溃疡55人进行呋喃硝胺与De-Nol单盲、随机治疗试验。味哺硝胺与De-Nol6周治愈率分别是71.4％和70.4％(P>0.05)。两者均未见明显副作用。胃粘膜幽门弯曲菌检出率为96.2％,高于慢性胃炎对照组的76.5％(P<0.05),提示幽门弯曲菌可能与胃溃疡的发病有关。De-Nol组治疗前后幽门弯曲菌检出率为96.3％及65.4％(P<0.01),表明De-Nol有去除胃粘膜幽门弯曲菌的作用。

Fifty-five patients with benign gastric ulcer (GU) proved by endoscopy were randomly divided into ranitidine and De-Nol groups. The healing rates at six weeks were 71.4% and 70.4%. respectively(P>0.05). No obvious side effects of both medicines were found. The result showed that De-Nol can be the alternative to ranitidine for treating GU. Cam-Pylobacter pylori(CP) detected by Warthin-starry silver stains in antral mucosa was found in 52 of the 55 patients(96.2%) with GU which was higher than in 23 of the 30(76.5%) with chronic gastritis(P<0.05). The presence of CP before and after the treatment with De-Nol were 96.3%. 65.4%, respectively (P<0.01). This result showed the bactericidal effect of De-Nol. No significant relationship was found between the presence of CP and gastritic activity.