GnRH和HMG脉冲给药对下丘脑性闭经患者诱发排卵的临床疗效观察

CLINICAL STUDY ON OVULATION INDUCTION BY PULSATILE ADMINISTRATION OF GnRH AND HMG IN WOMEN WITH HYPOTHALAMIC AMENORRHEA

8例下丘脑性闭经(HA)不孕者,年龄23～34岁,对克罗米酚和中医中药无效,在自动输液泵控制卜经静脉脉冲输注GnRH诱发排卵,结果2.5～6.25ug/90min剂量下2个治疗周期(23～36天)无反应,而10～20ug/90min剂量下9个治疗周期(11～23天)有7个周期发生了直径大于18mm的优势卵泡发育,4例妊娠。3个HMG脉冲治疗(4.9375～18.75U/90min,皮下)周期(14～20天)均出现了多卵泡发育。

Eight women with hypothalamic amenorrhea (HA) aged 23~34 years, failed to respond to clomiphene and were also no effect to traditional Chinese medicine. Pulsatile administration of GnRH(Relisoim) realized by automatic infusion pump were tried to induce ovulation. Two cycles (23~36 days) of GnRH treatment with the dosage of 2. 5~6. 25μg/ 9(min resulted in unresponsive. But in the dosage of 10~20μg/9(min, 7/9 of treatment cycles (11~23 days) had development of dominant follicles which were more than 18mm in diameter and 4 of the patients became pregnant. The multiple iollicular growth follows 3 HMG treatment cycles (14~23 days) with pulse of 4.6875-18.75μ/90min subcutaneously.