高原藏族酒精性肝病的超微病理学研究

ULTRASTRUCTURAL PATHOLOGY STUDY ON HIGH ALTITUDE TIBETAN ALCOHOLI LIVER DISOASE

探讨高原藏族酒精性肝病患者肝脏病变的超微病理学改变及其发生机制 ;方法 :经临床确定的 2 0例酒精性肝病患者肝穿标本电镜观察 ;结果 :①肝细胞主要为大泡性脂变 ,肝细胞坏死灶形成伴中性粒细胞浸润 ;②窦周隙贮脂细胞活化形成胶原纤维、肝细胞间纤维化致星芒状和条索状纤维间隔形成 ;③肝细胞内滑面内质网增生 ,偶见巨大线粒体 ;结论 :洒精性肝病纤维化形成的主要细胞是贮脂细胞 ,其次是肝细胞 ,一旦纤维化形成发展致肝硬变 ,很难恢复。

To investigate the ultrasuctural characteristic of high altitude Tibetan alcotolic liver disease and its pathogenesis .Methods:20 pathological samples gained through liver puncture were obesrved used electron microscope.Results:①Liver cell degeneration including and fatty degeneration focal ballooning,decreasa in liver size,focal encrosis with neutrophil infiltration.②Pericellular fatty cells activated and formed collagen,the fibrosis among hepatic cells was just like asstars.③The smooth endoplasmic reticulum of hepatic cells was hyperplasia,occasional giant mitochondrion.Conclusions:The fibrosis of alcoholic liver disease was fatty deposited cell firstly,and the hepatic cell secondly.Once fibrosis formed ,the liver cirrhosis developed and difficuitly to recover.