核基质与肿瘤病毒

Nuclear Matrix and Tumor Virus

核基质对维持细胞核形态结构和功能非常重要 ,在DNA复制、转录 ,RNA加工转运等过程中起支持作用。细胞恶变以及肿瘤细胞由低度变成高度恶性的过程中 ,都会发生恶性转化。多少年来 ,关于恶性转化时细胞核形态及生化改变的分子机理一直未阐明 ,最近这方面的研究取得了显著进展。现就恶性转化过程中 ,核基质与肿瘤病毒的关系 ,以及它自身所发生的生化变化作一阐述 ,这对探讨细胞恶性转化的分子机制有着重要的生物学意义。

The nuclear matrix is very important to maintaining the nuclear structural integrity and specific genomic functions.The nuclear matrix provides structural support for several processes such as DNA replication,transcription,and RNA splicing and transport.Malignant transformation occurs during malignant changes of cells and the process of tumor cells changing from low grade to high grade malignancy.The molecular mechanisms about the morphological and biochemical changes of the cell nucleus during the process of malignant transformation have not been elucidated for many years.Recently,the studies on the aspect have made great progress.In this paper,the relationship between nuclear matrix and tumor virus and its biochemical changes during the process of malignant transformation are reviewed,which may have important biological significances in the research of the molecular mechanisms of malignant transformation.