探讨肿瘤控制概率模型中各参数的取值变化对结果的影响

An Investigation on how the Estimated Result Changes with Various Values of Parameters in the Tumor Control Probability Model.

目的 探讨肿瘤控制概率 (TCP)计算模型中各参数的取值变化对计算结果的影响。方法 在假设某一参数取不同的值 ,而其他参数取假设的参考值的情况下 ,利用TCP计算模型进行计算并画出TCP与肿瘤半径的关系曲线 ,然后分析参数取值的变化对计算结果产生的影响。结果 在对TCP计算结果产生影响的参数中 ,吸收剂量、肿瘤体积、辐射敏感性、肿瘤中克隆源性细胞的潜在倍增时间的变化对TCP计算结果影响较大 ,而细胞密度、DNA单链断裂修复速率与再敏感化速率对结果的影响较小。结论 使用TCP评估治疗效果时必须注意肿瘤生物学参数的准确性 ,否则会导致结果评估的失误。

Objective To investigate the change degree of the estimated result affected by various values of the parameters in Tumor Control Probability (TCP)model.Methods For the main parameters in TCP model,supposing one is variable,at the same time the other parameters are invariable hypothetic values,the TCP results were calculated one by one,then the change degree of the calculated result affected by various values of this parameter were analyzed.Results In all parameters of the TCP model,the change of absorbed dose?tumor volume?radiosensitivity and the potential doubling time of the clonogen affect the TCP result more obviously than cell density?the repair velocity of single DNA-strand and velocity of resensitivity.Conclusion If using TCP to evaluate the radiotherapy effects,the exact values of parameters in TCP model are needed to avoid the misevaluation.