乳腺癌中c-met及p53表达与血管生成的关系

Relationship Between c-met, p53 Expression in Breast Carcinoma and Tumor Angiogenesis

目的 探讨c met及 p5 3表达在乳腺癌血管生成中的作用及其临床意义。 方法 应用SP免疫组化方法和计算机图像分析技术 ,对 80例乳腺癌、2 0例乳腺纤维腺瘤的微血管计数 (MVC)和c met及 p5 3蛋白的表达进行定量测定。结果 乳腺癌组织中MVC和c met及 p5 3的阳性表达与乳腺癌的组织学分级、腋窝淋巴结转移及肿瘤分期有关(P<0 .0 1)。MVC在c met及p5 3表达阳性者明显高于c met及 p5 3表达阴性者 ,两者间差异有显著性意义 (P <0 .0 1)。结论 c met及 p5 3共同参与调控乳腺癌的肿瘤血管生成。

Objective To find the role of oncogene c-met and suppressor gene p53 in the process of tumor angiogenesis and their clinical significance. [WT5”HZ]Methods [WT5”BZ]By immunohistochemical method and computer image analysis technique, microvessel count and c-met, p53 protein expression were quantitatively determined in 80 cases of breast carcinoma and 20 cases of breast fibroadenoma. [WT5”HZ]Results [WT5”BZ]The high microvessel count and the positive expression of c-met, p53 were significantly correlated with histologic grade, lymph node metastasis and the stage of the tumor (P<0.01). The high microvessel count was significantly correlated with the positive expression of c-met and p53 (P<0.01).[WT5”HZ]Conclusion [WT5”BZ]Both oncogene c-met and suppressor gene p53 modulate tumor angiogenesis of breast carcinoma. [WT5”HZ]