消化性溃疡并出血患者外周血T淋巴细胞亚群及NK细胞的研究

SUBCLASSES OF T LYMPHOCYTE AND NATURAL KILL CELLS FROM PATIENTS WITH PEPTIC ULCER AND GASTROINTESTINAL BLEEDING

目的 :观察消化性溃疡与免疫功能之间的关系。方法 :采用APAPP方法 ,检测了 71例十二指肠球部溃疡(Du)并出血、2 2例胃溃疡 (Gu)并出血、19例急性胃粘膜病变 (AGML)患者及 2 8例正常对照者外周血T淋巴细胞亚群及自然杀伤细胞 (NK细胞 )的水平。结果 :仅十二指肠球部溃疡并出血患者CD4水平 (2 9.2 2± 6 )显著高于对照组 (2 5 .86± 5 .3) (P <0 .0 1)。结论 :十二指肠球部溃疡并出血患者存在有免疫功能增强现象 ;

Objective:To investigate the relationship between peptic ulcer disease and immunologic function. Methods:Subclasses of T lymphocyte and natural kill cells of peripheral blood from 71 patients with bleeding duodenal ucler, 22 patients with bleeding gastric ulcer,19 patients with acute gastric mucosal lesion and 28 healthy controls were detected by means of APAPP method. Results:Only the level of CD4 of patients with bleeding duodenal ulcer (29.22±6) were significantly higher than that of healthy controls (25.86±5.30)( P <0.01). Conclusions:There are remarkable immunoenhancements in patients with bleeding duodenal ulcer.Imbalance of immunologic function maybe play some role in the pathogenisis of bleeding duodenal ulcer.