血清βHCG、孕酮及雌二醇对宫外孕的诊断意义

SIGNIFICANCE OF SERUM βHCG,PROGESTERONE AND ESTRADIOL IN DIAGNOSIGN ECTOPIC PREGNANCY

目的 :研究和比较血清 βHCG、孕酮及雌二醇分别和协同对宫外孕诊断的意义。对象为 15名用手术诊断为宫外孕及 30名正常早孕的育龄妇女。方法 :用电化学发光法检测 βHCG、孕酮及雌二醇 ,t检验、卡方检验及Logistic回归评价 βHCG、孕酮及雌二醇对宫外孕的诊断意义。结果 :在宫外孕组 ,βHCG、孕酮及雌二醇分别是 :5 6 4 .89± 386 .81UI/L ,32 8.6 5± 15 6 .82nmol/L ,4 6 92 .5± 2 4 6 2 .5Pmol/L ,而正常早孕组则分别是 :5 0 73.4 5± 385 4 .2 6UI/L ,6 85 .2 4± 2 4 1.6 3nmol/L ,5 4 32 .5± 2 6 78.4Pmol/L ,其中 pHCG、孕酮两组比较P <0 .0 5。单用 βHCG诊断宫外孕的准确率为 73.3% ,与孕酮共同诊断的准确率为 93.3% ,两组比较有统计学意义。Logistic回归较低的pHCG、孕酮有利于宫外孕的诊断。结论 :pHCG是一个对宫外孕具有一定敏感性及特异性的诊断指标 ,但如果与孕酮共同分析 ,将进一步提高其敏感性及特异性。

Objective:To analyze the significance of β human chorionic gonadotropin (βHCG ), progesterone(P) and estradiol(E2 ) in diagnosing ectopic pregnancy. Method:The serum levels of βHCG, P and E2 were detected by Elecsys System in fifteen ectopic pregnancy patients and thirty early pregnancy women. The significant differences between these two groups were compared by t-test and the accurate rate between these hormones by Chi-square test and Logistic regression.Result:In ectopi pregnancy group the βHCG, P and E2 were 564.89+386. 81UI/L, 328.65±156.82nmol/L, 4692.5 ±2462. 5 Pmol/L and in early pregnancy group, they were 564.89±38{5. 81UI/L, 328.65±156.82nmol/L, 4692. 5±2462. 5 Pmol/L. Comparing with two group, the βHCG and P in ectopic pregnancy were lower than that in early pregnancy( P <0.05). The accurate rate of βHCG alone was 73.3%, but that of βHCG and P were 93.3%( P <0.05). In Logistic regression, the lower β HCG and P was more possibility than higher βHCG and P.Conclusion:βHCG alone can be a diagnosis index in the ectopi pregnancy, but β HCG and P have a high accurate rate of diagnosing ectopic pregnancy.