吡喹酮对日本血吸虫卵孵化影响的研究

STUDY ON THE EFFECT OF PRAZIOUANTEL ON HATCHING SCHISTOSOMA JAPONIVUM EGGS

本文比较了吡喹酮(PQT)、氯化钙(CaCl_2)、吡喹酮+氯化钙(PQT+CaCl_2)和吡喹酮+氯化钠(PQT+NaCl)在体外条件下对日本血吸虫毛蚴孵出的影响。结果证明,在25℃,100μg/ml的PQT有促进毛蚴孵出的作用,药物作用30min,毛蚴孵出率达34.2％。低渗透压的CaCl_2溶液(31mOsM)对毛蚴孵出无明显影响,但与PQT协同作用时,可进一步促进毛蚴孵出,两者协同作用5min,毛蚴孵出率达38.2％。

In this study, the effects of praziquantel, CaCl2 combination of prziquantel with CaCl2 and a combination of prziquantel with NaCl on hatching of S.japonicum eggs in vitro were compared.The result showed that praziquantel （100μg/ml） accelerated the miracidia to hatch from eggs at 25℃ and the hatching rate of miracidia reached 34.2% after incubation.CaCl2 alone under low osmotic pressure （31m OsM） has no effect on hatching of egg but a combination of praziquantel and CaCl2 could further promote miracidia to hatch from eggs.The hatching rate of miracidia was 38.2% after 5min incubation.