HLA-ABC,HLA-DR,ICAM-1在乙型肝炎肝细胞表达的意义

THE SIGNIFICANCE OF HLA-ABC,HLA-DR AND ICAM-L EXPRESSION IN LIVER TISSUE WITH HEPATITIS B

为进一步探讨HLA-ABC.HIA-DR.ICAM-1在乙型肝炎肝细胞损伤中的作用.利用标记链菌素亲生物蛋白(LSAB)法对98例乙型肝炎肝穿组织进行HLA-ABC,HLA-DR,ICAM-1检测。结果显示HLA-ABC,ICAM-1在乙型肝炎肝细胞存在广泛表达,且与肝脏病变程度有关,HLA-DR也有一定程度表达,其阳性率分别为85.7％,83.7％,26.5％。阳性表达多位于肝细胞炎性病变或坏死区,常伴有不同程度炎性细胞浸润。提示HLA-ABC,ICAM-1的在肝细胞广泛表达在乙型肝炎发病中起重要作用。HLA-DR异常表达也一定程度参与了乙肝发病。这些免疫有关分子为T淋巴细胞识别杀伤HBV感染肝细胞提供了必要的分子基础,不仅与乙型肝炎肝细胞损伤有关,而且对肝内病毒的清除可能有一定的作用。

The liver tissues of 98 patients with hepatitis B were biosied and the expression of HLA-ABC, HLA-DR and ICAM-1 observed by immunohistochemical technique, the results showed that HLA-ABC and ICAM-1 were extensively expressed in the hepatocytes and the intencity of staining correted with the degree of hepatocellular injury, HLA-DR molecules were also observed to be expressed, but only in the lower level. The positive rates of hepalocytes for HLA - ABC, ICAM- 1 and HLA- DR were 85.7%, 83.7% and 26.5% respectively. The positive expression were often distributed in inflammatory or necrosis areas mostly accompanied with infiltration of inflammatory cells. It was suggested that HLA- ABC, ICAM - 1 as well as HLA - DR play important role in mechanism of hepatitis B and killing of HBV infected hepatocytes.