饮酒习惯对HCV感染者预后影响的研究

A EPIDEMIOLOGICAL STUDY ON DRIKING HABIT ASSOCIATION WITH CHRINIC OF HCV INFECTER

为研究饮酒习惯对HCV感染者慢性化的影响,我们收集142例HCV感染者的资料,以病程>6mon,白蛋白/球蛋白<1.5和/或ALT>40u者、或临床确有为慢性丙型肝炎病例为慢性HC,分入病例组,共76例;对不符合慢性HC标准者列为对照组,66例。结果显示:病例组有饮酒习惯的比例明显高于对照组(x=8.75,P<0.003,OR=2.79),经性别分层分析:男性OR=2.65,女性OR=4.29,OR_总=3.30,提示女性HCV感染者饮酒较男性更易发展成慢性肝病;饮酒量<100g/次、OR=3.18,>300g/次、OR=5.45,饮酒量与慢性丙型肝炎呈相关关系;持续饮酒≤5年、OR=1.74。6-15年、OR=3.51,>15年、OR=5.10,饮酒年限越长.其慢性化的危险性越大。说明饮酒可能是导致HCV感染慢性化的重要危险因素。因此,积极开展健康教育,提高人们的自我保健意识,规劝HCV感染者戒酒可能是预防HCV感染者慢性化的重要措施之一。

In order to analysis drinking habit association with chronic of HCV infecter. Method We adopted case-control study. 142 cases of HCV were collected. Among those cases as "a case group" were defined disesae courses were over 6 months, albumin/globulin &lt;1.5 and/or ALT&gt;40 units, othes be defined as "a control group". Being compared the drinking habit of both groups, Results It was showed that the drinking habit were positive association with chronic HC. Drinking hahit in case group and control group were difference Significantly. Stratified analysis showed females easer chronic than males in drinking habit. The more increasing the amount of drinking each time and being continuanced.Gonclusions Drinking habit may be has one of the risk factors of chronic of HCV infection. It’s benifit giving drinking habit to HCV infecter.