摘要
为探讨氯氮平与舒必利对精神分裂症患者体重影响的差别,将540名患者随机分为两组,分别服用氯氮平或舒必利,并对两组治疗前、治疗两个月及治疗一年测量体重并进行统计学分析。结果,两组患者体重在治疗两个月均不同程度的增加,且两组间无差异性;长期服药则舒必利组继续增加,氯氮平组基本不变。提示:两药对精神分裂症患者体重影响早期基本一致,而后期则舒必利影响较大。
In order to explore the difference of effects of clozaping and sulpiride on weights of schizopyrenics, 540 patients were randomly divided into 2 groups, which repectively took clozapine and sulpiride, weights measured at pretreatment, in the 2nd month and one year of treatment,and statistic analyses conducted.It was found that in the 2nd month of treatment,weights of both the 2 groups increase in varying degrees, and there was no diffeerence between the 2 groups; If long treated, the weight of sulpiride proup continued to increase,while clozapine group didn't change by and large. This suggested in the early, effects of the 2 drugs on weight were besicaly consistant, in the later,the effect of sulpiride was greater.
