口服一次量氯氮平后健康成人脑电活动的动态变化

The Dynamic Changes of Healthy Adult's EEG After the Once Oral Clozapine

为探讨氧氮平对健康成人脑电活动的影响,采用自身前后对照的方法比较健康成人服用一次量25mg氯氮平前后0.5、1、2、3、4、5、6、8、12、24小时脑电能量变化。结果,服用一次量25mg氯氮平后,α_3频段O_1、O_2导联,β频段O_2导联能量在第5～6小时较服药前显著降低(P<0.05),第24小时基本恢复用药前水平;α_2频段O_2导联,α_3频段F_8导联,B频段F_8、O_1导联能量有降低趋势,但未达显著水平(P>0.05);α_1频段F_3、F_7、F_8、C_3、T_4导联,δ频段F_7、T_4导联,θ频段F_7、T_3、T_4、T_5、T_6导联能量第5～6小时较用药前显著增高(P<0.05),第12～24小时基本恢复用药前水平;α_1频段Fp_1、F_4、T_3、C_4、P_3、T_5、T_6导联,θ频段P_3,O_1、O_2导联,δ频段T_3、T_5、T_6、O_1导联能量有增高趋势,但未达显著水平(P>0.05)。提示氯氮平对健康成人脑电活动的主要影响是α_1、δ、θ频段能量增高,α_2、α_3、β频段能量降低。

To study the effect of clozapine on the electrical activity of healthyadult's brain. Changes of electrical energy of healthy adult was companed using self preand post-control method before 25mg clozapine per os and at the one second, 1st, 2nd, 3rd, 4th, 5th, 6th, 8th, 12th, and 24th hours after oral administration. Results :After the once oral administration of clozapine,the energies of O1 and O2leads of α3 frequence domain, of O2 of β at 5th -6th hours were significantly lower than that of pre-administra-tion,and at 24th hour basically recovered to the level of pre-administration;the energies of O2 of α2, and F8 of α3, and F8 and O1 and O1 of β showed decreasing tredn, but were not significant(P>0. 05);at 5th -6th hours,the energies of F3,F7,F8,C3and T4of α1, of F7, F4 of δ, and of F7、 T3、 T4、 T5、 T6 of θ were significantly higher than that of pre-dministratian (P<0. 05),and at 12th -24th hours basically recoverd to the levels of pre-administration;the energies of Fp1,F4,T3,C4,P3,T5 and T6of α1of P3,O1 and O2, of θ,and of T3,T5,T6 and O1 of δ showed increasing trend,but were not significant (P >0. 05). The main effects of clozapine on electrical of healthy adult's brain were the increased energies of α1 ,δ and θ,and α2,α3and β.