摘要
为进一步认识氯氮平与其他抗精神病药物致粒细胞缺乏的差异,按标准对收集的、关于氯氮平与其他抗精神病药致粒细胞缺乏的对照研究论文结果作Meta分析。结果:(1)氯氮平与其他抗精神病药物导致粒细胞缺乏有非常显著性差异(X^2=11.20,df=1,P<0.01);(2)氯氮平引起粒细胞缺乏的危验性是其他抗精神病药物的8.8倍(OR=8.8);(3)病因学分数:EF_(暴露)因素=0.88,即氯氮平治疗组中出现粒缺者,88％是由氯氮平引起的,EF_(总体)=0.88,即在全部被治疗的精神分裂症出现粒缺者,88％由氯氮平引起。提示,氯氮平引起粒细胞缺乏效应显著高于其他抗精神病药物。
to further understand the difference of agranulocytosis by clozapine or other antipsychotics. Meta analyses were made for the results of control study's article about agranulocytosis by clozapine or other antipsychotics. Results: (1)there was significant difference in agranulotics(P<0. 01) ; (2)the agranulotosis risk by clozapine was 8. 8 times as high as by others(or=8. 8);(3)etiology fraction:EFexposure factor=0. 88, i. e. among the patients in clozapine group, 88 % was caused by clozapine; EFtotal = 0. 88,i. e. among all the treated patients, 88 % was caused by clozapine. These suggeted that agranulocytosis effect by clozapine was significantly higher than that by other antipsychotics.
