中药对淋巴细胞型白血病小鼠细胞膜流动性的影响

The Effect of Herbal Tonic on the Membrane Fluidity of the Mice Suffered from Lymphatic Leukemia

本实验通过应用荧光偏振技术观察了中药益气养阴方和补气养血方治疗前后,淋巴细胞型白血病小鼠(L_(7212))红细胞及淋巴细胞膜流动性的变化,结果表明两方药可以通过降低淋巴细胞膜的流动性,改善膜的结构和功能发挥抗白血病的作用。淋巴细胞膜流动性的异常可能对白血病的早期诊断有意义。

By using fluorescence polarizatiorl technology,the authors have studied variations in the membrane fluidity of red blood cell and spleen lymphocytes of the mice with lymphatic leukemia (L7212)untreated or treated by the compound tonic of traditional Chinese medicine decoction of reinforcing Qi(气)and nourishing Yin(阴)and decoction of reinforcing Qi and nourishing blood.It was not only confirmed that the membrane fluidity of malignant lymphocytes increased more greatly,but also discovered that the variations could appear in early period of leukemia.The membrane fluidity of lymphoeytes of the mice with leukemia treated by the herbal tonic could drop to normal level.But the membrane fluidity of the red blood cell between the normal mice(615)and the leukemia mice(L7212),untreated or treated by the herbal tonic,had no significant difference. Result.the above mentioned suggests the herbal tonic could resist leukemia by reducing the membrane fluidity of the lymphocytes and improving structure and function of the membrane.