高迁移率族蛋白-1在脓毒症发病中的作用与意义

THE SIGNIFICANCE AND POTENTIAL ROLE OF HIGH MOBILITY GROUP-1 PROTEIN (HMG-1) IN SEPSIS

既往普遍认为 ,“早期”致炎细胞因子是引起机体失控性炎症反应与组织损害的关键介质。新近的研究发现 ,高迁移率族蛋白 1(HMG 1)可能作为新的“晚期”炎症因子参与了内毒素的致病过程。本文扼要介绍了HMG 1在严重创 (烧 )伤后脓毒症发生、发展中的作用及其诱生机制 ,并对其潜在应用价值进行了分析。深入了解和研究HMG 1,可能有助于从全新的角度认识脓毒症和多器官损害的发病机制与临床意义 ,并为探索其防治方法提供新的思路。

It is previously recognized that release of early proinflammatory cytokines such as tumor necrosis factor α and interleukin 1 can mediate the development of systemic inflammatory response and subsequent tissue injury. High mobility group 1 protein (HMG 1), a ubiquitous DNA binding protein, was recently identified as a potential late mediator of delayed endotoxin lethality. This review covers the new role of HMG 1 in the pathogenesis of posttraumatic or postburn sepsis, the potential mechanisms regulating its synthesis as well as release during inflammatory process, and the possible significance as a therapeutic target. The discovery of a cytokine activity for HMG 1 might be of importance to contribute to understanding of sepsis with subsequent multiple organ dysfunction and guiding the utilization of innovative therapies.