从再狭窄发生的分子机制探讨基因治疗的策略
摘要
基因治疗血管重建术后再狭窄是心血管领域中的重要课题 ,针对血管内膜增生的分子机制 ,血管内膜损伤修复、细胞内信号转导的阻滞、细胞周期的调控及细胞外基质的抑制等几个方面的治疗策略起重要作用。基因治疗抑制效应与增强效应并存 ,其不良影响还难以估计 ,联合治疗是今后发展的方向。
出处
《国外医学（生理病理科学与临床分册）》
2002年第4期337-339,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金
国家自然科学基金 :395 0 0 14 0
参考文献18
-
1Ohno T, Gordon D, San H, et al. Gene therapy for vascular smooth muscle cell proliferation after arterial injury [J]. Science, 1994,265: 781-784.
-
2Luo Z,Sata M,Nguyen T, et al. Adenovirus-mediated delivery of fas ligand inhabits intimal hyperplasia after balloon injury in immunollogically primed animal[J]. Circulation, 1999,99:1776 - 1779.
-
3Yonemitsu,Kaneda Y,Tanaka S, et al. Transfer of wild-type p53 gene effectively inhabits vascular smooth muscle cell proliferation in vitro and in vivo[J]. Circ Res, 1998,82:147 - 156.
-
4McArthur JG, Qian H, CitronD, et al. P27-p16 Chimera: a superior antiproliferative for the prevention of neointimal hyperplasia[J]. Mol Ther,2001,3(1):8-13.
-
5Kipshidze N, Keane E, Stein D, et al. Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model[J]. Catheter Cardiovasc Interv,2001,54(2):247-256.
-
6Cioffi CL, Garay M, Johnston JF, et al. Selective inhabition of A-raf and C-raf mRNA expression by antisense oligodexynucleotides in rat vascular smooth muscle cell[J]. Mol Pharmacol, 1997,51:383 - 389.
-
7Indolfi C,Stabile E, Coppola C, et al. Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals[J] .Cird Res,2001,88(3):319-324.
-
8Autieri MV, Yue TL, Ferstein GZ, et al. Antisense oligonucleotides to the p65 subunit of NF-kB inhabit human vascular smooth muscle cell ad-herance and proliferation and prevent neointima formation in rat carotid arteries[J]. Biochem Biophys Res Commun, 1995,213:827 - 836.
-
9Kawauchi, Suzuki J, Morishita R, et al. Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2Fdecoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates [J]. Circ Res,2000, 87(11):1063 - 1068.
-
10Maillard L, Van Belle E, Rio F, et al. Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries[J]. Gene Ther, 2000,7 (16): 1353-1361.
-
1朱庆平.前列环素刺激因子[J].国外医学（生理病理科学与临床分册）,2002,22(4):335-337.
-
2孟凡义,季红,汪月增,刘海川,周绮.骨髓增生异常综合征的细胞周期分布和临床分析[J].军医进修学院学报,1992,13(1):88-89.
-
3顾晋,刘鼎新.应激性溃疡的胃粘膜细胞动力学实验研究[J].中华医学杂志,1991,71(11):630-632. 被引量：1
-
4王安才.血管重建及其治疗学意义[J].中国临床药理学与治疗学杂志,1998,3(1):29-29.
-
5陈颖颖,吕江峰,王庆红,刘鹏,王静.糖耐量异常病人血清胱抑素C与颈动脉IMT相关性[J].青岛大学医学院学报,2014,50(6):525-526. 被引量：1
-
6刘利红.辛伐他汀对老年2型糖尿病颈动脉内中膜厚度的影响[J].中国误诊学杂志,2008,8(21):5122-5123. 被引量：1
-
7王少青,钱学贤.单克隆抗体在心血管领域研究进展[J].中华内科杂志,1990,29(12):749-751.
-
8沈法荣.如何进一步提高心脏再同步治疗慢性心力衰竭的疗效[J].浙江医学,2010(11):1588-1590. 被引量：1
-
9杭燕.血管紧张素Ⅱ受体拮抗剂在心血管领域中的应用[J].中华医学写作杂志,2003,10(21):1984-1985.
-
10吕金兰,杨文波,王英丽.碎裂QRS波的研究进展[J].医学综述,2015,21(5):862-865. 被引量：6
