早产儿及低体重儿四种支原体感染状况研究

Study of 4 mycoplasmas infection in preterm infants and low birth weight infants.

为了解早产儿、低体重儿人型支原体 (Mh)、解脲脲原体 (Uu)、生殖支原体 (Mg) ,发酵支原体 (Mf)等 4种支原体的感染状况 ,我们于 1997年～ 1998年分别收集了 2 7例早产儿和 2 1例低体重儿的咽拭子标本应用套式PCR (nPCR)法进行上述 4种支原体特异性核酸检测。结果早产儿和低体重儿的Mh阳性率分别为 92 6 %、95 2 % ;Uu阳性率分别为 5 5 5 %、38 1%。Mh +Uu合并感染状况严重 ,分别为 5 5 5 %、33 3%。Mg只有 1例阳性 ,Mf无阳性病例发现。无论是早产儿 ,还是低体重儿 ,剖宫产与阴道产的各种支原体检出率无差别 (P均 <0 0 5 )。剖宫产娩出儿咽部查出支原体可确认为宫内感染 ,由此可见 ,支原体宫内感染状况严重。本文并就支原体感染与早产和新生儿出生低体重的发生原因进行了讨论。

Objective: To study infection with Mycoplasma hominis (Mh)?Ureaplasma urealyticum(Uu)?Mycoplasma genitalium(Mg)?Mycoplasma fermentans (Mf) in the preterm infants and low birth weigth infants.Methods: Applying nested Polymerase Chain Reaction (nPCR) detected 4 Mycoplasmas.Results: In 27 preterm infants and 21 low birth weinght infants:Postive rate of Mh was 92 6%,95 2%; Postive rate of Uu was 55 6%,38 1%;Postive rate of Mh+Uu was 55 6%; 1 postive case of Mg was detected and without Mf postive case was detected.Conclution: Here exsists serious intrauterine infection of Mycoplasmas. It hints that there is obvious corre-lation between Mycoplasmas infection and birth of preterm infants and low birth weight infants.