血瘀证心脑血管疾病血小板聚集与释放功能的同步观察及其临床意义

Detections Simultaneously on the Platelet Function of Aggregation and Release in Patients with Cardio-Cerebral Vascular Diseases Associated with Blood Stasis and Their Clinical Significance

采用电阻抗法和光电比浊法分别测定了血瘀证缺血性心脏病患者的血小板聚集活性,结果显示全血及血浆血小板聚集率均有所增高。继而采用光电比浊法和放射免疫法对血瘀证缺血性脑卒中患者同步检测血小板聚集活性、聚集后β-血栓球蛋白(β-TG)释放量以及血浆β-TG 含量。结果表明,体外血小板聚集率和随之产生的β-TG 释放量并未显示一定的相关性,仅仅检测血小板聚集率有时并不能反映其活性程度。脑卒中急性期主要表现为聚集后β-TG 释放量以及血浆β-TG 含量明显增高,恢复期血小板几种活性指标虽有所改善,但仍较健康组异常增高。

The authors determined the platelet aggregation(PA) activity respectively with electric impedancity and photgelectric turbidimetry in patients with ischemic cardio-cerebral vascular diseases associated with blood stasis.The results showed the PA activities were elevated both in whole blood and plasma.Then,the authors detected simultaneously the PA activity and amount of post-aggregation β-thromboglobulin(β-TG)releasing and also in vivo amount of spontaneous plasma releasing of β-TG with photoelectric turbidimetry and RIA methods with blood stasis.The results showed,during the acute phase of stroke,a high activated state of platelet existed,expressed as significant elevation both of the amount of β-TG releasing of post-aggregation and plasma β-TG level.However,no definite correlation between rate of PA and subsequent amount of β-TG releasing was found,and detection of aggregation rate alone did not disclose truely the state of activation.As compared with the acute phase,during the recovery stage of stroke in which the clinical symptom of blood stasis was improved,the plasma β-TG level declined significantly,however,was still higher than in normal controls;amount of releasing β-TG was declining which denoted that the platelet functions were reducing then,but were still in a higher state of activation.These results suggested that there were changes both in number and quality of platelet in patients with blood stasis.