化瘀通腑法治疗子宫内膜异位症临床及实验研究

Study on the Treatment of Endometriosis with Removing Blood Stasis and Purgation Method

用化瘀通腑的内异1号丸治疗盆腔子宫内膜异位症76例,总有效率为80.26%。治疗前后分别作实验室检验,结果血液流变学包括全血比粘度(低切比)、红细胞聚集指数、全血还原粘度、血沉、血沉方程 K 值、血浆比粘度均有显著改变(P<0.05),血清IgA,IgG、IgM、C_3均有显著下降(P<0.001),OKT_8升高,OKT_4/OKT_8下降(P<0.001),经期血浆 PGF_(2a)下降(P<0.001)。提示化瘀通腑法和它的代表方内异1号丸具有改变血液流变性、改善微循环、调整机体免疫功能和降低经期血浆前列腺素浓度的作用,从而使患者的临床症状和体征得到改善。

According to the method of differentiation of symptom complexes of traditiomal Chinese medicine(TCM),endometriosisis a disease of blood stasis and mass in the lower portion of abdomen. 76 cases were treated by TCM prescription named endometriotic pill No 1 with rhubarbas the main ingredient.The chief functions of the rhubarb were removing blood stasis,disintegrating mass and purgation.The total effective rate was 80.26%.Among them,the effective rate of dysmenorrhea was 88.89%,that of pelvic pain was 66.72%,that of intercourse pain 72.12%,and diminishing in size of mass or nodule 22.15%;3 cases of 22 infertility gotpregnant(13.63%).The results revealed that the endometriotic pill No 1 yielded distinct improvement in the treatment of endometriosis,including clinical symptoms and signs,laboratory assay of blood rheotogy,serum Ig,subgroup of T lympho cyte(OKT system)and PG.