正常晚期妊娠及妊娠高血压综合征血浆中循环内皮细胞与一氧化氮及内皮素相关性研究

Study on correlation of circulating endothelial cells with nitric oxide and endothelin in normal late pregnant women and pregnancy-induced hypertension syndrome.

目的探讨正常晚期妊娠和妊娠高血压综合征孕妇血浆中循环内皮细胞 (CEC)数与一氧化氮 (NO)及内皮素 (ET)浓度变化与妊娠高血压综合征发病的相关性。方法采用高效液相色谱分析技术、密度梯度离心法及放射免疫分析技术测定 2 0例正常晚期妊娠妇女 (A组 )及 43例妊娠高血压综合征患者 (B组 )血浆中 CEC数、NO及 ET-1浓度的变化。结果 B组 CEC数、ET-1(12 .45± 3 .19,10 1.49± 2 4.19)显著高于 A组 (7.67± 0 .84,76.5 3± 16.0 3 ,P<0 .0 1) ;B组 NO含量 (1717.86± 3 89.2 9)低于 A组 (2 946.15± 3 5 4.69,P<0 .0 1)。结论 CEC增多是血管内皮细胞损伤的确切标志 ,NO和

Objective To study the correlation of the circulating endothelial cells(CEC) with nitric oxide(NO) and endothelin(ET 1) in normal late pregnant women and pregnancy induced hypertension syndrome.Methods CEC,NO and ET 1 were measured in 20 normal late pregnant women(A group) and 43 cases with pregnancy induced hypertension syndrome(B group)by liquid chromatography analysis technique,density gradient centrifugation and radio immunity analysis.Results CEC in B group(12.45±3.19,101.49±24.19) was obviously higher than that in A group(7.67±0.84,76.53±16.03,P<0.01).NO in group B(1717.86±389.29) was lower than that in group A(2946.15±354.69,P<0.01).Conclusion The increase of CEC symbolizes the vascular endothelium injury.NO and ET 1 are involved in the pathogenesis of pregnancy induced hypertension.