血清PCⅠ和PCⅢ联合测定诊断肝硬化的临床意义

Clinical Significance of Determing Serum PCⅠ and PCⅢ in the Diagnosis of Hepatic Cirrhosis

测定血清Ⅰ型前胶原 (PCⅠ )、Ⅲ型前胶原 (PCⅢ )的含量 ,用于诊断肝硬化的临床评价。用自行研制的PCⅠ、PCⅢ放免试剂盒 ,同时测定 10 0名健康献血员和 16 2例各种肝病患者血清中PCⅠ、PCⅢ的含量。结果显示 ,肝硬化组与肝硬化合并肝癌组血清PCⅠ显著升高 ,而其他各组不升高。PCⅢ在急性肝炎、原发性肝癌组升高 ,慢性活动性肝炎和肝硬化组升高最显著 ,慢性迁延性肝炎和其他肝病组不升高。并且 ,血清PCⅠ与PCⅢ水平不相关 (r =0 .14 5 ,P >0 .0 5 )。结论 :测定血清PCⅢ对提示早期肝纤维化及其发展有意义 ,而PCⅠ对判断肝硬化有重要价值 ,因此我们认为血清PCⅠ和PCⅢ联合测定 。

To observe the clinical significance of determing serum procollagen type Ⅰ(PCⅠ) and procollagen type Ⅲ(PCⅢ) levels in the diagnosis of hepatic cirrhosis, the PCⅠ and PCⅢ RIA kit established by ourselevs were used to determine PCⅠ and PCⅢ in 100 normal controls and 162 patients with various liver diseases. The results showed that the levels of serum PCⅠ in two hepatic cirrhotic goups were significantly higher than those in the other goups( P <0.001). The serum PCⅢ levels were: highest in patients with hepatic cirrhosis and chronic active hepatitis; high in patients with acute hepatitis and primary hepatic carcinoma without cirrhosis and no significantly high in patients with chronic persistent hepatitis, cholelithiasis and other liver diseases. There was no correlation between serum PCⅠ and PCⅢ ( r =0.145, P >0.05).Conclusion: The results suggest that the determination of serum PCⅠ and PCⅢ levels has significant value in the diagnosis of hepatic fibrosis advanced towards cirrhosis.