乙型肝炎病毒复制对肝纤维化进程的作用

The Role of the Replication of Hepatitis B Virus in the Progress of Liver Fibrosis

探讨乙型肝炎病毒不同复制程度对肝纤维化进程的作用。173例乙型肝炎患者分为 6组 :慢性肝炎轻、中、重度 3组 ,肝硬化Child -PughA、B、C级 3组 ;采用放射免疫分析法测定慢性乙型肝炎、肝硬化患者血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量 ,并同时测定HBV -DNA ,按其阳性、阴性进行分组比较。当HBV -DNA(+)时与HBV -DNA(- )时 ,血清IL - 6、IL - 8、PⅢP、c -Ⅳ含量相比较 ,除在轻度组、C级组无显著差异外 (P >0 .0 5 ) ,其余 4组皆有统计学意义 ,以重度组、A级组为著 (P <0 .0 1)。提示 :乙型肝炎病毒活跃复制可促进肝星状细胞的活化 ,从而在肝纤维化的起始。

This article is to investigate the role of the replication of hepatitis B virus in the progress of liver fibrosis, 173 patients with hepatitis B virus were divided into six groups: chronic hepatitis B(CHB)-mild, -middle, -severe groups, Child-Pugh(CP)-A,-B,-C groups, and every group was again devided into two sub-groups according to HBV-DNA. The serum IL-6, IL-8,PⅢP,c-IV in the patients were measured by RIA. The results were compared between HBV-DNA(+) and HBV-DNA(-) sub-groups. Except the case in CHB-mild and CP-C groups( P >0.05),the serum levels of IL-6, IL-8, PⅢP,c-Ⅳ were significantly higher in HBV-DNA positive sub-group than that in HBV-DNA negative sub-group( P <0.05), especially in CHB-severe and CP-A groups( P <0.01).The results suggest that hepatitis B virus may activate the hepatic starlike cell and make this progress continue, so the active replication of hepatitis B virus play an important role in the beginning stage and the progress stage of liver fibrosis.