“恩纳”用于气管表面麻醉的动物实验研究

The Study of EMLA in Surface Anesthesia during Tracheal Intubation

目的 :研究“恩纳”用于气管插管表面麻醉的可行性。方法 :2 0只成年白兔随机分为两组 ,经耳缘静脉推注安定 0 5mg/kg,氯胺酮 1mg/kg全身麻醉后 ,用直喉镜暴露声门 ,实验组插入直径 3 5mm ,前端 5cm均匀涂有“恩纳”乳剂的气管导管 ;对照组插入同型导管 ,但不使用“恩纳”。观察气管插管后的耐受情况及麻醉苏醒后的呼吸道反应 ;插管 4小时后 ,取气管导管接触段行光镜检查。结果 :两组白兔经全身麻醉气管插管后 ,生命体征平稳 ,嘴唇红润 ,呼吸通畅 ,没有分泌物增加现象 ;麻醉作用消失后 ,实验组白兔一般能耐受气管导管 ,没有呛咳 ,打喷嚏的现象 (0 /10 )。而对照组白兔一般均有呛咳 ,打喷嚏的现象 (10 /10 ) ;两组白兔气管标本均未见形态学改变 ,双肺观察也无水肿、充血、分泌物增加的现象。结论 :“恩纳”乳剂用于气管插管 ,能减轻导管在麻醉维持期及拔管后的应激反应 ,减少术后喉部并发症。

Objective:To study the feasibility of EMLA in endotracheal intubation in rat.Methods:Twenty rats were divided into two groups randomly.Diazepam(0.5mg/kg)and Ketamine(1mg/kg)were given through ear vein.Laboratory group was intubated into the 3.5mm tracheal tube with EMLA smear the 5cm long of the tip and the control group was intubated the same type tube without EMLA smearing.Observe the tolerance of tracheal tube and the respiratory effect in rats.Results:Both two groups showed the stable vital signs during the period under anesthesia.After the effect of anesthesia vanishing laboratory group rat can tolerance the tube well than the control.There were no morphological differences of tracheal mucosa between the two groups.Conclusions:The use of EMLA in intubation may reduce the stress reaction during and after anesthesia.