宫腔操作与沙眼衣原体感染关系的研究

Relationship between intrauterine manipulation and Chlamydia trachomatis infection

沙眼衣原体是一种细胞内寄生、具有独特生活周期的原核微生物,是女性生殖道感染的常见病原体.近年来,其感染呈急骤上升趋势.它是引起女性不孕,尤其是输卵管性不孕的重要致病因素.为了探讨沙眼衣原体的可能感染途径,作者对220例不孕不育妇女,作宫颈上皮细胞沙眼衣原体抗原检测,并分成无、有宫腔操作组及单、多次宫腔操作组进行对照研究.现将结果报告如下.

Objective To study the relationship between intrauterine manipulation and Chlamydia trachomatis infection.Methods Antigen of Chlamydia trachomatis in cervical epithelial cells of 220 infertile women was assayed with CLEARVEEW kit made in Britain.The patients were divided into groups with and without histories of intrauterine manipulation,with histories of single manipulation and repeated manipulations;and,inter-group comparisons of Chlamydial infection rates were made.Results Of 156 with intrauterine manipulation,106 were positive for the antigen,accounting for 67.95% while of 64 withoutintrauterine manipulation,21 were positive,constituting 32.81%,the difference being very significant (P<0.001).Of 77with single manipulation,52 were positive,accounting for 67.53%,and of 79 with repeated manipulations,54 were positive,making up 68.35%,the difference being not significant (P>0.05).Conclusion Intrauterine manipulation is associated withChlamydia trachomatis infection,but there is not significant differce between single and repeated manipulations.It is suggested that routine examination of Chlamydia trachomatis in cervical epithelial cells should be carried out before intrauterine manipulation,especially for the first time.In the case of intrauterine manipulation without examination of Chlamydia trachomatis beforehand,routine preventive therapy with sensitive antibiotics such as macrolides is recommended.