骨形成蛋白(BMP)-2/4,IA型BMP受体及Smad1、4、5在Tca8113舌癌细胞中的表达及意义

Expression of BMP-2/4,BMPR-IA and Smad1,4,5 in Tca8113 cell

目的 认识和分析BMPs及其信号传导因子与口腔鳞状细胞癌发生、发展的可能关系。方法 用免疫组织化学方法检测BMP - 2 / 4 ,IA型BMP受体及Smad1,4 ,5在Tca8113细胞中表达并分析其意义。结果 BMP - 2 / 4 ,IA型BMP受体及Smad1,4 ,5在Tca8113细胞中有表达。其中 ,在胞浆中发现有BMP - 2 / 4的阳性信号 ,在胞膜中有IA型BMP受体的阳性信号 ,在胞质、胞核中有Smad1,4 ,5的强阳性表达。结论 BMPs及其信号传导因子与口腔鳞状细胞癌发生。

Objective To study the relationships between bone morphogenectic proteins(BMPs),BMP receptors type IA,Smad1,4,5 and squamous cell carcinoma of oral epithelia.Methods Expressions of BMP-2/4,BMPR-IA and Smad1,4,5 in Tca8113 cell were analyzed by immunohistochemistry.Results All of Tca8113 cell showed positive staining for BMP-2/4 which consistently exhibited in cytoplasm.Positive signals of BMPR-IA were found in cytomembrane consistently.Positive signals of Smad1,4,5 in nucleoplasm were obtained consistently.Conclusion BMP-2/4,BMPR-IA and Smad1,4,5 might be involved in occurrence and development of squamous cell carcinoma of oral epithelium.