通督活血汤对兔血小板聚集功能的影响

Approach to Mechanism of Curative Effect of Tongdu Huoxue Tang on Lumber Spinal Stenosis ——Effect on Rabbits Platelet Aggregation

本实验结果显示,通督活血汤对由二磷酸腺苷和花生四种酸诱导的血小板聚集反应均表现出较强的抑制作用,其抗聚集功效随着用药量的增加呈现出量效关系。认为抗血小板聚集是该方治疗椎管狭窄症间歇性疼痛、跛行的疗效机理之一。

The experiment has shown that the inhibiting effect of Tongdu Huoxue Tang ( TDHXT ) on platelet aggregation induced by ATP and arachidonic acid(AA), when drug was given,platelet aggregation were decreased with increasing dose and this inhibiting effect was dropping with the decreasing of dose.The anthors suggested that TDHXT was effective to relieve inttermittent claudication on lumber spinal stenosis,it was one of the mechanism of curative effect to inhibit the function of blood aggregation.