阻塞性黄疸患者血浆内毒素和血清肿瘤坏死因子α水平的研究

PLASMA ENDOTOXIN AND SERUM TUMOR NECROSIS FACTOR-α LEVELS IN HUMAN OBSTRUCTIVE JAUNDICE

检测29例恶性肿瘤所致的阻塞性黄疸患者的外周血血浆ET、血清TNF－α水平，发现血浆ET及血清TNF－α水平均明显升高，二者有一定的相关关系（r=0．4531，P＜0．02），两者水平与术前黄疸持续时间，血清Bil和AKP水平及术后并发症发生率亦有一定关系。

Twenty-nine patients with obstructive jaundice caused by malignant tumors were included in this study. Peripheral blood was sampled for the determinations of plasma endotoxin (ET)and serum tumor necrosis factor-α(TNF-α)level. Researches were also made on the correlation between the two and their relation with other clinical parameters. The results showed that the occurence of endotoyemia, the average value of plasma ET and serum TNF-α level in peripheral blood were all obviously higher in this group of jaundiced patients than in normal control. Endotoxemia was proved to be correlated with the elevation of TNFα level (r= 0. 4531, P<0.02)and both may be involved in the pathogenesis of obstructive jaundice. The authors found the examination of ET before operation could somehow predict the postoperative complications.