摘要
Background: Long term follow up of the Optic Neuritis Treatment Trial (ONTT) cohort to evaluate brain magnetic resonance imaging (MRI) in patients who have not developed clinically definite multiple sclerosis. Objective: To determine th e proportion of patients with monosymptomatic optic neuritis who manifest new br ain MRI lesions without having developed clinically definite multiple sclerosis 10 to 14 years after enrollment in the ONTT. Design: Observational study. Settin g: Fourteen clinical centers. Participants: One hundred eight ONTT patients who had not developed clinically definite multiple sclerosis 10 to 14 years after st udy enrollment. Main Outcome Measure: Development of new T2 lesions on follow u p brain MRI. Results: At least 1 T2 lesion 3 mm or larger was observed on follow up MRIs in 27 (44%) of 61 patients with normal baseline MRIs. Additional lesi ons (≥3 mm) were present on follow up MRIs in 26 (74%) of 35 patients with ab normal baseline MRIs. Conclusions: A subset of patients with monosymptomatic opt ic neuritis manifest neither clinical signs nor MRI evidence of demyelination af ter more than 10 years of follow up. In other cases followed up for this length of time, MRI signal abnormalities may accumulate without causing new clinical m anifestations of multiple sclerosis. This information is useful in counseling pa tients who develop first episode optic neuritis.
Background: Long term follow up of the Optic Neuritis Treatment Trial (ONTT) cohort to evaluate brain magnetic resonance imaging (MRI) in patients who have not developed clinically definite multiple sclerosis. Objective: To determine th e proportion of patients with monosymptomatic optic neuritis who manifest new br ain MRI lesions without having developed clinically definite multiple sclerosis 10 to 14 years after enrollment in the ONTT. Design: Observational study. Settin g: Fourteen clinical centers. Participants: One hundred eight ONTT patients who had not developed clinically definite multiple sclerosis 10 to 14 years after st udy enrollment. Main Outcome Measure: Development of new T2 lesions on follow u p brain MRI. Results: At least 1 T2 lesion 3 mm or larger was observed on follow up MRIs in 27 (44%) of 61 patients with normal baseline MRIs. Additional lesi ons (≥3 mm) were present on follow up MRIs in 26 (74%) of 35 patients with ab normal baseline MRIs. Conclusions: A subset of patients with monosymptomatic opt ic neuritis manifest neither clinical signs nor MRI evidence of demyelination af ter more than 10 years of follow up. In other cases followed up for this length of time, MRI signal abnormalities may accumulate without causing new clinical m anifestations of multiple sclerosis. This information is useful in counseling pa tients who develop first episode optic neuritis.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第3期12-12,共1页
Digest of the World Core Medical Journals:Clinical Neurology
