摘要
Objectives. This study of premonitory symptoms in migraine was performed to document the frequency, duration, and types of symptoms in a large group of migr aine patients. Background. Prodrome importance continues to be debated. Interv ention early in the migraine attack is assuming more importance and necessitates better knowledge of the prodrome. Methods. A total of 893 migraine patients ( IHS 1.1-1.7) were evaluated at first visit. Prodrome frequency, duration, and c haracteristics were analyzed in the total migraine population IHS 1.1-1.7 and I HS 1.1-1.6 migraine. Results. A total of 32.9%of IHS migraine 1.1 1.6 patie nts reported prodrome symptoms with an average of 9.42 hours. IHS 1.1-1.7 migra ine reported 29.7%and 6.8 hours, respectively. The most commonest symptoms were tiredness, mood change, and gastrointestinal symptoms; all three of these sympt oms were present together in 17%of the patients with prodrome. The duration of prodrome was less than 1 hour in 45.1%, 1-2 hours in 13.6%, 2-4 hours in 15. 0%, 4-12 hours in 13.1%, and greater than 12 hours in 13.2%. IHS 1.1-1.7 pa tients showed similar findings. IHS 1.1-1.6 patients with prodrome differed fro m patients without prodrome in having more triggers as a whole (P <..01), more i ndividual triggers including alcohol (P <..01), hormones (P <..01), light (P <.. 001), not eating (P <..05), perfume (P <..01), stress (P <..01), and weather cha nges (P <.05), a longer duration of aura (P <.05), longer time between aura and headache (P <.05), more aura with no headache (P <..05), longer time to peak of headache (P <..05), longer time to respond to triptan (P <.05), longer maximum d uration of headache (P <.05), and more headache associated nausea (P <..05), mor e headache associated running of the nose or tearing of (the eyes (P <.05), more postdrome syndrome (P <..05), and longer duration of postdrome syndrome (P <..0 01). Conclusions. This study provides a portrait of prodrome in a large cohort of patients. It highlights differences between patients with prodrome and patie nts not having prodrome, and it draws attention to the potential of preventing t he headache phase of the acute migraine attack.
Objectives. This study of premonitory symptoms in migraine was performed to document the frequency, duration, and types of symptoms in a large group of migr aine patients. Background. Prodrome importance continues to be debated. Interv ention early in the migraine attack is assuming more importance and necessitates better knowledge of the prodrome. Methods. A total of 893 migraine patients ( IHS 1.1-1.7) were evaluated at first visit. Prodrome frequency, duration, and c haracteristics were analyzed in the total migraine population IHS 1.1-1.7 and I HS 1.1-1.6 migraine. Results. A total of 32.9%of IHS migraine 1.1 1.6 patie nts reported prodrome symptoms with an average of 9.42 hours. IHS 1.1-1.7 migra ine reported 29.7%and 6.8 hours, respectively. The most commonest symptoms were tiredness, mood change, and gastrointestinal symptoms; all three of these sympt oms were present together in 17%of the patients with prodrome. The duration of prodrome was less than 1 hour in 45.1%, 1-2 hours in 13.6%, 2-4 hours in 15. 0%, 4-12 hours in 13.1%, and greater than 12 hours in 13.2%. IHS 1.1-1.7 pa tients showed similar findings. IHS 1.1-1.6 patients with prodrome differed fro m patients without prodrome in having more triggers as a whole (P <..01), more i ndividual triggers including alcohol (P <..01), hormones (P <..01), light (P <.. 001), not eating (P <..05), perfume (P <..01), stress (P <..01), and weather cha nges (P <.05), a longer duration of aura (P <.05), longer time between aura and headache (P <.05), more aura with no headache (P <..05), longer time to peak of headache (P <..05), longer time to respond to triptan (P <.05), longer maximum d uration of headache (P <.05), and more headache associated nausea (P <..05), mor e headache associated running of the nose or tearing of (the eyes (P <.05), more postdrome syndrome (P <..05), and longer duration of postdrome syndrome (P <..0 01). Conclusions. This study provides a portrait of prodrome in a large cohort of patients. It highlights differences between patients with prodrome and patie nts not having prodrome, and it draws attention to the potential of preventing t he headache phase of the acute migraine attack.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第3期38-39,共2页
Digest of the World Core Medical Journals:Clinical Neurology
