摘要
Background and Purpose:Multiple studies have suggested an association between Chlamydia pneumoniae and Mycoplasma pneumoniae infectio n and cardiovascular disease. We investigated whether the risk of cerebrovascula r disease is associated with Legionella pneumophila infection and the aggregate number/infectious burden of these atypical respiratory pathogens.Methods:One hu ndred patients aged >65 years admitted with acute stroke or transient ischemic a ttack (TIA) and 87 control patients admitted concurrently with acute noncardiopu lmonary,noninfective conditions were recruited prospectively. Using enzyme-link ed immunosorbent assay (ELISA) kits, we previously reported the seroprevalences of C pneumoniae and M pneumoniae in these patients. We have now determined these roprevalences of L pneumophila IgG and IgM in this cohort of patients using ELI SA. Results:The seroprevalences of L pneumophila IgG and IgM were 29%(n=91) an d 12%(n=81) in the stroke/TIA group and 22%(n=86) and 10%(n=72) in the contro ls, respectively. Using logistic regression to adjust for age, sex, hypertension , smoking, diabetes, ischemic heart disease, and ischemic ECG, the odds ratios f or stroke/TIA in relation to L pneumophila IgG and IgM were 1.52 (95%CI,0.70 to 3.28; P=0.29) and 1.49 (95%CI, 0.45 to 4.90; P=0.51),respectively. The odds ra tios in relation to IgG seropositivity for 1, 2, or 3 atypical respiratory patho gens after adjustment were 3.89 (95%CI, 1.13 to 13.33), 2.00 (95%CI, 0.64 to 6 .21), and 6.67 (95%CI, 1.22 to 37.04), respectively (P=0.06).Conclusions:L pne umophila seropositivity is not significantly associated with stroke/TIA. However , the risk of stroke/TIA appears to be associated with the aggregate number of c hronic infectious burden of atypical respiratory pathoeens such as C pneumoniae, M pneumoniae, and L pneumophila.
Background and Purpose:Multiple studies have suggested an association between Chlamydia pneumoniae and Mycoplasma pneumoniae infectio n and cardiovascular disease. We investigated whether the risk of cerebrovascula r disease is associated with Legionella pneumophila infection and the aggregate number/infectious burden of these atypical respiratory pathogens.Methods:One hu ndred patients aged >65 years admitted with acute stroke or transient ischemic a ttack (TIA) and 87 control patients admitted concurrently with acute noncardiopu lmonary,noninfective conditions were recruited prospectively. Using enzyme-link ed immunosorbent assay (ELISA) kits, we previously reported the seroprevalences of C pneumoniae and M pneumoniae in these patients. We have now determined these roprevalences of L pneumophila IgG and IgM in this cohort of patients using ELI SA. Results:The seroprevalences of L pneumophila IgG and IgM were 29%(n=91) an d 12%(n=81) in the stroke/TIA group and 22%(n=86) and 10%(n=72) in the contro ls, respectively. Using logistic regression to adjust for age, sex, hypertension , smoking, diabetes, ischemic heart disease, and ischemic ECG, the odds ratios f or stroke/TIA in relation to L pneumophila IgG and IgM were 1.52 (95%CI,0.70 to 3.28; P=0.29) and 1.49 (95%CI, 0.45 to 4.90; P=0.51),respectively. The odds ra tios in relation to IgG seropositivity for 1, 2, or 3 atypical respiratory patho gens after adjustment were 3.89 (95%CI, 1.13 to 13.33), 2.00 (95%CI, 0.64 to 6 .21), and 6.67 (95%CI, 1.22 to 37.04), respectively (P=0.06).Conclusions:L pne umophila seropositivity is not significantly associated with stroke/TIA. However , the risk of stroke/TIA appears to be associated with the aggregate number of c hronic infectious burden of atypical respiratory pathoeens such as C pneumoniae, M pneumoniae, and L pneumophila.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第7期53-54,共2页
Digest of the World Core Medical Journals:Clinical Neurology
