摘要
Objectives: To determine in vivo cortical acetylcholineste- rase(AChE) activity and cognitive effects in subjects with mild Alzheimer’s d isease (AD, n=14) prior to and after 12 weeks of donepezil therapy. Methods: Cog nitive and N-[11C]methyl-piperidin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET) assessments before and after donepezil therapy. Result s: Analysis of the PET data revealed mean (temporal,parietal, and frontal) corti cal donepezil induced AChE inhibition of 19.1%(SD 9.4%) (t=-7.9; p < 0.0001). Enzyme inhibition was most robust in the anterior cingulate cortex (24.2%(6.9 %), t=-14.1; p < 0.0001). Donepezil induced cortical inhibition of AChE activi ty correlated with changes in the Stroop Color Word interference scores (R2=0.59 , p < 0.01), but not with primary memory test scores. Analysis of the Stroop tes t data indicated that subjects with AChE inhibition greater than the median valu e (> 22.2%) had improved scores on the Stroop Color Word Test compared with sub jects with less inhibition who had stable to worsening scores (t=-2.7; p < 0.05 ). Conclusions:Donepezil induced inhibition of cortical AChE enzyme activity is modest in patients with mild AD. The degree of cortical enzyme inhibition correl ates with changes in executive and attentional functions.
Objectives: To determine in vivo cortical acetylcholineste- rase(AChE) activity and cognitive effects in subjects with mild Alzheimer's d isease (AD, n=14) prior to and after 12 weeks of donepezil therapy. Methods: Cog nitive and N-[11C]methyl-piperidin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET) assessments before and after donepezil therapy. Result s: Analysis of the PET data revealed mean (temporal,parietal, and frontal) corti cal donepezil induced AChE inhibition of 19.1%(SD 9.4%) (t=-7.9; p < 0.0001). Enzyme inhibition was most robust in the anterior cingulate cortex (24.2%(6.9 %), t=-14.1; p < 0.0001). Donepezil induced cortical inhibition of AChE activi ty correlated with changes in the Stroop Color Word interference scores (R2=0.59 , p < 0.01), but not with primary memory test scores. Analysis of the Stroop tes t data indicated that subjects with AChE inhibition greater than the median valu e (> 22.2%) had improved scores on the Stroop Color Word Test compared with sub jects with less inhibition who had stable to worsening scores (t=-2.7; p < 0.05 ). Conclusions:Donepezil induced inhibition of cortical AChE enzyme activity is modest in patients with mild AD. The degree of cortical enzyme inhibition correl ates with changes in executive and attentional functions.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第8期19-20,共2页
Digest of the World Core Medical Journals:Clinical Neurology
