摘要
Reduced cerebrovascular reactivity has been reported in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopat hy (CADASIL), and the measurement has been suggested as a useful surrogate marke r of disease progression. Previous studies have not determined whether cerebral autoregulation is also impaired. We measured dynamic cerebral autoregulation and carbon dioxide reactivity in 24 nondemented CADASIL patients and 20 controls, u sing transcranial Doppler ultrasound (TCD). No impairment in either measure was found in the CADASIL group. We conclude that either cerebrovascular reactivity a nd autoregulation are not impaired in early disease, or that TCD may not be a su fficiently sensitive tool to detect haemodynamic changes in early disease.TCD is unlikely to be useful for disease monitoring in patients without advanced disea se.
Reduced cerebrovascular reactivity has been reported in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopat hy (CADASIL), and the measurement has been suggested as a useful surrogate marke r of disease progression. Previous studies have not determined whether cerebral autoregulation is also impaired. We measured dynamic cerebral autoregulation and carbon dioxide reactivity in 24 nondemented CADASIL patients and 20 controls, u sing transcranial Doppler ultrasound (TCD). No impairment in either measure was found in the CADASIL group. We conclude that either cerebrovascular reactivity a nd autoregulation are not impaired in early disease, or that TCD may not be a su fficiently sensitive tool to detect haemodynamic changes in early disease.TCD is unlikely to be useful for disease monitoring in patients without advanced disea se.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第8期42-42,共1页
Digest of the World Core Medical Journals:Clinical Neurology
