摘要
Background: Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow- up of representative US cohorts. Objective: To examine mortality rates, duration of survival, causes of death, and the contribution of AD to the risk of mortali ty in an aging community-based cohort, controlling for other predictors. Design : Fifteen-year prospective epidemiological study. Mortality rates per 1000 pers on-years and the population-attributable risk of mortality were determined. Co x proportional hazards models were used to estimate relative risk of mortality d ue to AD, adjusting for relevant covariates. Death certificates were abstracted for listed causes of death. Setting: A largely blue-collar rural community in s outh-western Pennsylvania. Participants: A community-based cohort of 1670 adul ts 65 years and older at study enrollment. Main Outcome Measure: Mortality. Resu lts: In the overall cohort, AD was a significant predictor of mortality, with a hazard ratio of 1.4 after adjusting for covariates. The population-attributable risk of mortality from AD was 4.9%based on the same model. Examining the sexes separately, AD increased mortality risk only among women. Death certificates of AD subjects were more likely to list dementia/AD, other brain disorders, pneumo nia, and dehydration, and less likely to include cancer. Conclusions: Alzheimer disease was responsible for 4.9%of the deaths in this elderly cohort. Alzheimer disease increased the risk of mortality 40%in the cohort as a whole and separa tely in women but not in men. The mean (SD) duration of survival with AD was 5.9 (3.7) years, and longer with earlier age at onset.
Background: Alzheimer disease (AD) is considered a leading cause of death, but few studies have examined the contribution of AD to mortality based on follow- up of representative US cohorts. Objective: To examine mortality rates, duration of survival, causes of death, and the contribution of AD to the risk of mortali ty in an aging community-based cohort, controlling for other predictors. Design : Fifteen-year prospective epidemiological study. Mortality rates per 1000 pers on-years and the population-attributable risk of mortality were determined. Co x proportional hazards models were used to estimate relative risk of mortality d ue to AD, adjusting for relevant covariates. Death certificates were abstracted for listed causes of death. Setting: A largely blue-collar rural community in s outh-western Pennsylvania. Participants: A community-based cohort of 1670 adul ts 65 years and older at study enrollment. Main Outcome Measure: Mortality. Resu lts: In the overall cohort, AD was a significant predictor of mortality, with a hazard ratio of 1.4 after adjusting for covariates. The population-attributable risk of mortality from AD was 4.9%based on the same model. Examining the sexes separately, AD increased mortality risk only among women. Death certificates of AD subjects were more likely to list dementia/AD, other brain disorders, pneumo nia, and dehydration, and less likely to include cancer. Conclusions: Alzheimer disease was responsible for 4.9%of the deaths in this elderly cohort. Alzheimer disease increased the risk of mortality 40%in the cohort as a whole and separa tely in women but not in men. The mean (SD) duration of survival with AD was 5.9 (3.7) years, and longer with earlier age at onset.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第9期21-22,共2页
Digest of the World Core Medical Journals:Clinical Neurology
