摘要
Objective: To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia. Methods: Neuropsychiatric, anthropometric, laboratory, and other assessments were conducted for 392 partici pants of a 1901 to 1902 birth cohort first examined at age 70. Follow-up examin ations were at ages 75, 79, 81, 83, 85, and 88. Information on those lost to fol low-up was collected from case records, hospital linkage system, and death cert ificates. Cox proportional hazards regression examined lipid levels at ages 70, 75, and 79 and incident dementia between ages 70 and 88. Results: Increasing cho lesterol levels (per mmol/L) at ages 70 (hazard ratio [HR] 0.77, 95%CI: 0.61 to 0.96, p=0.02), 75 (HR 0.70, CI: 0.52 to 0.93, p=0.01), and 79 (HR 0.73, CI: 0.55 to 0.98, p=0.04) were associated with a reduced risk of dementia between ages 79 and 88. Examination of cholesterol levels in quartiles showed that the risk reduction was apparent only among the highest quartile at ages 70 (8.03 to 11.44 mmol/L [311 to 442 mg/dL]; HR 0.31, CI: 0.11 to 0.85, p=0.03), 75 (7.03 to 9. 29 mmol/L [272 to 359 mg/dL]; HR 0.20, CI: 0.05 to 0.75, p=0.02), and 79 (6.82 t o 9.10 mmol/L [264 to 352 mg/dL];HR 0.45, CI: 0.17 to 1.23, p=0.12). Triglycerid e levels were not associated with dementia. Conclusions: High cholesterol in lat e life was associated with decreased dementia risk, which is in contrast to prev ious studies suggesting high cholesterol in mid-life is a risk factor for later dementia. The conflicting results may be explained by the timing of the cholest erol measurements in relationship to age and the clinical onset of dementia.
Objective: To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia. Methods: Neuropsychiatric, anthropometric, laboratory, and other assessments were conducted for 392 partici pants of a 1901 to 1902 birth cohort first examined at age 70. Follow-up examin ations were at ages 75, 79, 81, 83, 85, and 88. Information on those lost to fol low-up was collected from case records, hospital linkage system, and death cert ificates. Cox proportional hazards regression examined lipid levels at ages 70, 75, and 79 and incident dementia between ages 70 and 88. Results: Increasing cho lesterol levels (per mmol/L) at ages 70 (hazard ratio [HR] 0.77, 95%CI: 0.61 to 0.96, p=0.02), 75 (HR 0.70, CI: 0.52 to 0.93, p=0.01), and 79 (HR 0.73, CI: 0.55 to 0.98, p=0.04) were associated with a reduced risk of dementia between ages 79 and 88. Examination of cholesterol levels in quartiles showed that the risk reduction was apparent only among the highest quartile at ages 70 (8.03 to 11.44 mmol/L [311 to 442 mg/dL]; HR 0.31, CI: 0.11 to 0.85, p=0.03), 75 (7.03 to 9. 29 mmol/L [272 to 359 mg/dL]; HR 0.20, CI: 0.05 to 0.75, p=0.02), and 79 (6.82 t o 9.10 mmol/L [264 to 352 mg/dL];HR 0.45, CI: 0.17 to 1.23, p=0.12). Triglycerid e levels were not associated with dementia. Conclusions: High cholesterol in lat e life was associated with decreased dementia risk, which is in contrast to prev ious studies suggesting high cholesterol in mid-life is a risk factor for later dementia. The conflicting results may be explained by the timing of the cholest erol measurements in relationship to age and the clinical onset of dementia.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第9期52-53,共2页
Digest of the World Core Medical Journals:Clinical Neurology
