摘要
Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10%of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS from unrelated SOD1-negative familial ALS families.These observations provide further evidence that PLS can be linked pathophysiologically to ALS.
Primary lateral sclerosis (PLS) is a diagnosis of exclusion in patients with progressive spinobulbar spasticity and could be part of the clinical spectrum of ALS. Unlike ALS, which is familial in 5 to 10%of the cases, PLS has been described as a sporadic disorder in adults. The authors report two patients with PLS from unrelated SOD1-negative familial ALS families.These observations provide further evidence that PLS can be linked pathophysiologically to ALS.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第9期56-56,共1页
Digest of the World Core Medical Journals:Clinical Neurology
