摘要
Objective: To examine brain maturation in adolescent girls with borderline p ersonality disorder (BPD) features using the P300 event- related potential. Met hods: One hundred twenty- three girls, aged 14- 19 yrs, were assigned to one o f 4 groups formed by the crossing of BPD features (< vs.≥ 5 BPD criteria) and m edian age ( < vs. > 16.5 yrs). P300 responses were measured while subjects perfo rmed a complex visual oddball task. Results: ANCOVAs of P300 amplitude- adjusti ng for variability associated with comorbid conduct disorder and depression symptoms- revealed a significant interaction . Among subjects without BPD features, aging was associated with the normal redu ction in visual P300 amplitude. Among subjects with BPD features, there were no age- related changes. Additional analyses, which tested the effects of BPD feat ures across the full age range, supported these findings. Conclusions: The prese nt findings suggest abnormal brain maturation among adolescent girls exhibiting features of BPD. Significance: These results support a hypothesis of altered bra in maturation in adolescents exhibiting BPD features at an early age. It is sugg ested that measures of brain maturation obtained during adolescence may improve our ability to predict BPD and comorbid disorders in adulthood.
Objective: To examine brain maturation in adolescent girls with borderline p ersonality disorder (BPD) features using the P300 event- related potential. Met hods: One hundred twenty- three girls, aged 14- 19 yrs, were assigned to one o f 4 groups formed by the crossing of BPD features (< vs.≥ 5 BPD criteria) and m edian age ( < vs. > 16.5 yrs). P300 responses were measured while subjects perfo rmed a complex visual oddball task. Results: ANCOVAs of P300 amplitude- adjusti ng for variability associated with comorbid conduct disorder and depression symptoms- revealed a significant interaction . Among subjects without BPD features, aging was associated with the normal redu ction in visual P300 amplitude. Among subjects with BPD features, there were no age- related changes. Additional analyses, which tested the effects of BPD feat ures across the full age range, supported these findings. Conclusions: The prese nt findings suggest abnormal brain maturation among adolescent girls exhibiting features of BPD. Significance: These results support a hypothesis of altered bra in maturation in adolescents exhibiting BPD features at an early age. It is sugg ested that measures of brain maturation obtained during adolescence may improve our ability to predict BPD and comorbid disorders in adulthood.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第10期14-15,共2页
Digest of the World Core Medical Journals:Clinical Neurology
