摘要
The anti- adhesion gel ADCON- L has been available since the end of the 199 0s. During disc surgery it can be applied to the spinal nerve roots and the dura mater spinalis in order to inhibit fibroblast migration and thus avoid postoper ative adhesions or excessive keloids, respectively. Due to the way ADCON- L wor ks, inadvertent, intraoperational dural lesions may stay open much longer than u sual because ADCON- L inhibits the natural healing process. Possible consequenc es are a chronic leakage of cerebrospinal fluid in combination with intracranial hypotension syndrome. We report on a patient who underwent lumbar disc surgery with application of ADCON- L gel. Postoperatively he suffered from acute headac he, nausea, and vomiting. A lumbar pseudomeningocele was demonstrated on magneti c resonance imaging (MRI). Furthermore, cranial MRI revealed bilateral, chronic subdural haematomata which indicated intracranial hypotension syndrome or contin uous leakage of cerebrospinal fluid at the lumbar site. With conservative treatm ent the problems were gradually reduced and eventually the subdural haematomata were no longer detected. The pseudomeningocele persisted over a 4 month period o f observation. Because of the complications we found, the local application of A DCON- L during lumbar disc surgery should be critically evaluated.
The anti- adhesion gel ADCON- L has been available since the end of the 199 0s. During disc surgery it can be applied to the spinal nerve roots and the dura mater spinalis in order to inhibit fibroblast migration and thus avoid postoper ative adhesions or excessive keloids, respectively. Due to the way ADCON- L wor ks, inadvertent, intraoperational dural lesions may stay open much longer than u sual because ADCON- L inhibits the natural healing process. Possible consequenc es are a chronic leakage of cerebrospinal fluid in combination with intracranial hypotension syndrome. We report on a patient who underwent lumbar disc surgery with application of ADCON- L gel. Postoperatively he suffered from acute headac he, nausea, and vomiting. A lumbar pseudomeningocele was demonstrated on magneti c resonance imaging (MRI). Furthermore, cranial MRI revealed bilateral, chronic subdural haematomata which indicated intracranial hypotension syndrome or contin uous leakage of cerebrospinal fluid at the lumbar site. With conservative treatm ent the problems were gradually reduced and eventually the subdural haematomata were no longer detected. The pseudomeningocele persisted over a 4 month period o f observation. Because of the complications we found, the local application of A DCON- L during lumbar disc surgery should be critically evaluated.
出处
《世界核心医学期刊文摘（神经病学分册）》
2005年第10期35-36,共2页
Digest of the World Core Medical Journals:Clinical Neurology
