具有灾难性抗磷脂综合征病史患者经氟伐他汀治疗后的局灶性癫痫发作

Focal seizures after treatment with fluvastatin in a patient with a history of catastrophic antiphospholipid syndrome

We report a 36-year-old woman with the occurrence of painful focal seizures of her left hand and the left leg. She also had focal motor seizures at the left corner of her mouth. The duration and frequency of the episodes increased over four days from a few seconds once a day to frequent intervals lasting more than four hours at a time. The symptoms appeared one day after start of the treatment with fluvastatin (40 mg) administered in order to diminish the endothelial activation induced by antiphospholipid antibo dies (aPL). The patient suffered from severe manifestations of the antiphospholi pid syndrome (APS)including Catastrophic Antiphospholipid Syndrome (CAPS, Ashers on’s syndrome). In this case a single 40 mg dose of oral fluvastatin was linked to seizures. After discontinuation of this treatment, the seizures immediately disappeared and the patient fully recovered without evidence of permanent neurol ogical damage. This data links statins to seizures in patients with compromised blood brain barrier such as APS.